RAD140 (TESTOLONE) DESCRIPTION
RAD140 (Testolone) is a potent, oral bioavailable, research nonsteroidal nonsteroidal androgen receptor modulator (SARM) devoloped as a future replacement for exogenous Testosterone replacement therapy (TRT) by Radius Health, Inc. Current RAD140 research focuses on the potential benefits of increasing muscle mass, fighting muscle wasting, skeletal wasting (osteoporosis), breast cancer and protecting brain cells. RAD140 Testolone has the chemical formula C20H16ClN5O2 and a molecular mass of 393.83 g mol−1.
THE RAD140 ANDROGEN RECEPTOR HAS PERFECT Affinity
RAD140 showed excellent affinity for the androgen receptor (Ki = 7 nM versus 29 nM for testosterone and 10 nM for dihydrotestosterone (DHT)) as well as good selectivity over other steroid hormone nuclear receptors, the closest off target receptor being the progesterone receptor (IC50 = 750 nM). vs 0.2 nM for progesterone). In vitro functional androgen agonist activity was confirmed in the C2C12 osteoblast differentiation assay, showing an EC50 of 0.1 nM (DHT = 0.05 nM).
AD140 EFFECTIVELY Stimulates MUSCLE MASS GROWTH
A clinical study published in 2011 examined the anabolic androgenic effect of RAD140 in young primates, male cynomolgous monkeys. Animal body weight results for 28 days of dosing with RAD140 at 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg are shown in the figure below:
In this study, mean weight gain was achieved only at the 0.1 mg/kg dose over the 28-day dose. A similar result was obtained in the 1.0 mg/kg dose group.
Significant and selective anabolic effect on muscles and bones, without strong androgenic side effects on other organs
It has strong neuroprotective effects, may be effective in preventing Alzheimer’s disease and related neurodegenerative disorders
Has the potential to fight breast cancer
May help treat serious diseases associated with muscle wasting
May help preserve brain cells and their proper function
May help treat osteoporosis
Helps build and maintain muscle mass
May help reduce excess fat
ADVANTAGES OF RAD140 OVER ANABOLIC STEROIDS
RAD140 (Testolone) is selective and primarily intended for movement in muscles and bones. Due to this selectivity, it does not cause strong androgenic negative effects on other organs, unlike anabolic steroids.
Similar to anabolic steroids, RAD140 can help achieve significant muscle gains, but has significantly fewer dangerous and unwanted side effects, and the potential health risks that steroid use can cause are many times lower than that:
RAD140 does not convert to Estrogen or DHT
RAD140 does not cause significant retention of water and salts
RAD140 does not cause increased Cortisol levels
RAD140 does not cause prostate enlargement
RAD140 does not cause kidney disease
RAD140 does not cause acne and oily skin
RAD140 does not cause swollen face
RAD140 does not cause aggression, explosiveness
RAD140 is extremely effective when administered orally (no injection required)