XSPIDER Product Description
RAD140 (TESTOLONE) DESCRIPTION
RAD140 (Testolone) is a potent, oral bioavailable, research nonsteroidal nonsteroidal androgen receptor modulator (SARM) devoloped as a future replacement for exogenous Testosterone replacement therapy (TRT) by Radius Health, Inc. Current RAD140 research focuses on the potential benefits of increasing muscle mass, fighting muscle wasting, skeletal wasting (osteoporosis), breast cancer and protecting brain cells. RAD140 Testolone has the chemical formula C20H16ClN5O2 and a molecular mass of 393.83 g mol−1.
THE RAD140 ANDROGEN RECEPTOR HAS PERFECT Affinity
RAD140 showed excellent affinity for the androgen receptor (Ki = 7 nM versus 29 nM for testosterone and 10 nM for dihydrotestosterone (DHT)) as well as good selectivity over other steroid hormone nuclear receptors, the closest off target receptor being the progesterone receptor (IC50 = 750 nM). vs 0.2 nM for progesterone). In vitro functional androgen agonist activity was confirmed in the C2C12 osteoblast differentiation assay, showing an EC50 of 0.1 nM (DHT = 0.05 nM).
AD140 EFFECTIVELY Stimulates MUSCLE MASS GROWTH
A clinical study published in 2011 examined the anabolic androgenic effect of RAD140 in young primates, male cynomolgous monkeys. Animal body weight results for 28 days of dosing with RAD140 at 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg are shown in the figure below:
RAD140 etkili kas kütlesinin büyümesini uyarır
In this study, mean weight gain was achieved only at the 0.1 mg/kg dose over the 28-day dose. A similar result was obtained in the 1.0 mg/kg dose group.
NEUROPROTECTIVE EFFECTS OF RAD140
A scientific study published in 2014 investigated the neuroprotective effects of rad140 in cultured rat neurons and male rat brain. Neuroprotection is an important neural action of endogenous androgens related to neural health and resilience against neurodegenerative diseases.
In cultured hippocampal neurons, RAD140 was as effective as testosterone in reducing cell death induced by apoptotic insults. Mechanistically, RAD140 neuroprotection was dependent on MAPK signaling, evidenced by upregulation of ERK phosphorylation and inhibition of protection by the MAPK kinase inhibitor U0126. More importantly, RAD140 was also neuroprotective in vivo using the rat kainate lesion model.
In experiments with gonadectomized, adult male rats, RAD140 has been shown to exhibit peripheral tissue-specific androgen action largely spared prostate, neural activity as shown by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of excitoxin kainate. These new findings demonstrate the first preclinical efficacy of a SARM in neuroprotective actions related to Alzheimer’s disease and related neurodegenerative diseases.
RAD140 (TESTOLONE) AND BODYBUILDING
Similar to anabolic steroids, RAD140 effectively stimulates the growth of muscle mass. However, its safety profile is significantly better compared to steroids. RAD140 has significantly fewer dangerous and unwanted side effects, and the potential health risks that anabolic steroid use can cause are many times lower. Therefore, RAD140 is also used (abuse) by bodybuilders, athletes and people who are trying to gain muscle figure, who want to achieve similar results when using steroids, but also want to eliminate / minimize possible unwanted side effects. We emphasize that RAD140 is not an approved nutritional supplement or stimulant for athletes: RAD140 is an experimental substance still under investigation, its long-term effects are not yet fully known and more research is needed. Note that the RAD140, like all our other products, is sold for scientific and research clinical use only.
RAD140 AND DOPING
While RAD140 is not illegal, it is illegal in professional sports. WADA (World Anti-Doping Agency) banned all Selective androgen receptor modulators (including RAD140) as early as 2008.
POSSIBLE BENEFITS OF RAD140 SCIENTIFICALLY RESEARCHED
Significant and selective anabolic effect on muscles and bones, without strong androgenic side effects on other organs
It has strong neuroprotective effects, may be effective in preventing Alzheimer’s disease and related neurodegenerative disorders
Has the potential to fight breast cancer
May help treat serious diseases associated with muscle wasting
May help preserve brain cells and their proper function
May help treat osteoporosis
Helps build and maintain muscle mass
May help reduce excess fat
ADVANTAGES OF RAD140 OVER ANABOLIC STEROIDS
RAD140 (Testolone) is selective and primarily intended for movement in muscles and bones. Due to this selectivity, it does not cause strong androgenic negative effects on other organs, unlike anabolic steroids.
Similar to anabolic steroids, RAD140 can help achieve significant muscle gains, but has significantly fewer dangerous and unwanted side effects, and the potential health risks that steroid use can cause are many times lower than that:
RAD140 does not convert to Estrogen or DHT
RAD140 does not cause significant retention of water and salts
RAD140 does not cause increased Cortisol levels
RAD140 does not cause prostate enlargement
RAD140 does not cause kidney disease
RAD140 does not cause acne and oily skin
RAD140 does not cause swollen face
RAD140 does not cause aggression, explosiveness
RAD140 is extremely effective when administered orally (no injection required)