Red Box Labs Consequence


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Product Description

SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression
Biochem/physiol Actions
SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.

 SARMs can be confusing, especially with many new ones appearing in the past couple of years. Sr9011 is one of those newer SARMs that people aren’t really using, because they don’t really get what the benefits are.

Is SR 9011 the same as SR 9009? If so, what’s the point in giving them different numbers? Well, there are subtle differences and I’m going to tell you what they are right now.

In this full Sr9011 bodybuilding guide, I’m going to tell you everything you need to know about this new research chemical with some fantastic benefits.

I will tell you how it works, and whether it’s best for bulking or cutting stacks. I’ll talk about dosing and cycling it. I’ll talk about the side effects and problems as well. Plus, we will discuss sr9011 vs sr9009, and how both of them compare to Cardarine, a very similar SARM.


Is Sr9011 A SARM?

A SARM is a Selective Androgen Receptor Modulator. That means that it selectively activates androgen receptors. This mostly means being a selective agonist of androgen receptors in bone and muscle tissue only.

Some SARMs are agonists of those androgen receptors, but can also be less targeted. S-23 and RAD-140 are the main SARMs that are very potent and closer to steroids because they less easily target muscle and bone tissue receptors. But here’s the thing. SR9011 isn’t a SARM at all. Its mechanism of action and its effects are completely different.

That’s the same with Sr 9009 and Cardarine. Both of which need to also be discussed within this review so you understand how they all subtly vary yet also achieve the same results.

How SR9011 Works

Once processed by the liver, SR9011 works in the same way as Sr9009, by increasing the constitutive repression of genes regulated by Rev-ErbA and Rev-ErbAB (Beta).

A repressor is a DNA binding protein (in the case of Sr9011 an artificial one) that inhibits gene expression.

In inhibiting the expression of genes regulated by Rev-Erba and Rev-ErbAB (Beta), it produces results described as “hormone and metabolic modulation”).

In studies, Activation of Rev-Erba in mice increased exercise capacity by increasing mitochondria counts in skeletal muscle. This is the same mechanism of action in both SR-9009 and SR-9011.

So what this is doing is basically affecting gene expression in a dose-dependent manner. In doing this it affects fatty acid processing, glucose production and availability, metabolism, and fat cell growth.

It even has a strong effect on the circadian rhythm (the natural desire to sleep and wake). This effect promotes better sleep and rest and increased wakefulness.

Before I talk specifically about bodybuilding benefits, I want to just mention the circadian rhythm thing. Sr9011 was observed in my studies to completely suppress the circadian pattern of expression in continually dark circumstances.

So, although this can promote wakefulness, and alertness, and make you feel incredibly rested, too much of it close to sleep can mean your body clock is messed up and you’ll end up struggling to sleep.

SR9011 Bodybuilding Benefits & Effects

 I’ve already talked about the body clock benefits, but let’s now go through everything in detail for you so that you can see the potential Sr9011 benefits you can derive.

  1. Its effect on circadian rhythm does mean you will be more alert, and also more regulated and rested during sleep as long as you do not take high doses close to the time go to bed.
  2. This is incredibly important. REV-ERB is central to lipid and glucose metabolism, by directly regulating them. This means you will get a significant energy boost.
  3. Also observed was increased gene expression in skeletal muscle. This appears to be the driver for an enhanced metabolic rate, with fatty acid transport into skeletal muscle tissue being enhanced. Put that together, and what you’ve got is the ability to work out harder and longer, and fuel muscle recovery far better than you can naturally.
  4. This increased metabolic rate can lead to weight loss, even on exactly the same calorie diet. Mice studies observed that even with the same daily food intake, mice lost around 10% of their bodyweight. Better than that, in another mouse study, specimens within groups given SR-9009 and SR-9011 lost on average 60% more weight than mice in the control group. Alongside this, they also demonstrated significant drops in cholesterol.
  5. Although it’s not a muscle builder in the same way as anabolic SARMs are, studies have noted that it can help your body regenerate microtears in muscle tissue faster:

Rev-Erb antagonists accelerate muscle regeneration following acute muscle injury by stimulating myoblast differentiation”

So although it’s not an aggressive muscle builder, it will help with recovery and muscle repair. That’s why stacking this research chemical alongside an anabolic SARM can mean that you build that aggressive new lean muscle mass even faster.

You’re also going to lose a ton of weight using this as well. On average, around 10% fat loss per cycle. One study noted:

“Taken together with the results from the CLAMS experiments, these data suggest that REV-ERB agonists increase energy expenditure by increasing fatty acid and glucose oxidation in the skeletal muscle.”

For me, this is really exciting, and exactly why I decided to try both SR9011 and SR9009. Now I use them to underpin every stack I do (unless I use Cardarine instead, which has similar effects in terms of increasing glucose and fatty acid energy availability).

Let me be clear here, this is what it’s going to do for you:

  • Increase available energy before, during, and after your workout
  • Supply increased energy directly to muscle tissue for faster recovery
  • Help to promote alertness and wakefulness
  • Increase rest and makes you feel happy
  • You will lose weight due to increased metabolic activity
  • Lower cholesterol levels
  • Reduce a low-calorie intake
  • Will increase your workout endurance levels

Overall, this is going to dramatically change your workout capacity and recovery. Used on its own, or stacked with anabolic SARMs, it’s going to increase energy availability, speed up recovery times, speed up muscle repair & growth, make you feel rested, burn more fat, and promote wakefulness.


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Red Box Labs Consequence

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